{"id":536,"date":"2026-10-18T20:20:11","date_gmt":"2026-10-18T12:20:11","guid":{"rendered":"https:\/\/www.next-bioinfo.tw\/?p=536"},"modified":"2026-10-18T20:57:11","modified_gmt":"2026-10-18T12:57:11","slug":"%e3%80%903d-genome%e3%80%91%e4%bd%95%e8%ac%82%e6%9f%93%e8%89%b2%e9%ab%94%e4%b8%89%e7%b6%ad%e7%b5%84%e7%b9%94-%e7%82%ba%e4%bd%95%e8%a6%81%e7%a0%94%e7%a9%b6%e6%9f%93%e8%89%b2%e8%b3%aa%e7%9a%84","status":"publish","type":"post","link":"https:\/\/www.next-bioinfo.tw\/en\/2026\/10\/%e3%80%903d-genome%e3%80%91%e4%bd%95%e8%ac%82%e6%9f%93%e8%89%b2%e9%ab%94%e4%b8%89%e7%b6%ad%e7%b5%84%e7%b9%94-%e7%82%ba%e4%bd%95%e8%a6%81%e7%a0%94%e7%a9%b6%e6%9f%93%e8%89%b2%e8%b3%aa%e7%9a%84\/","title":{"rendered":"\u30103D Genome\u3011\u4f55\u8b02\u67d3\u8272\u9ad4\u4e09\u7dad\u7d44\u7e54 &#8211; \u70ba\u4f55\u8981\u7814\u7a76\u67d3\u8272\u8cea\u7684\u4e09\u7dad\u7a7a\u9593\u76f8\u5c0d\u4f4d\u7f6e"},"content":{"rendered":"<p>\u4eba\u985e\u55ae\u5957\u57fa\u56e0\u7d44\u7d04\u5305\u542b 30 \u5104\u500b\u9e7c\u57fa\u5c0d\uff08bp\uff09\uff0c\u5982\u679c\u5c07\u5176\u4e2d\u7684 DNA \u96d9\u80a1\u87ba\u65cb\u5168\u90e8\u62c9\u76f4\uff0c\u7e3d\u9577\u5ea6\u7d04\u70ba 1 \u516c\u5c3a\u3002\u4e00\u822c\u4eba\u9ad4\u7d30\u80de\u5177\u6709\u5169\u5957\u57fa\u56e0\u7d44\uff0c\u56e0\u6b64 DNA \u7e3d\u9577\u5ea6\u7d04\u70ba 2 \u516c\u5c3a\uff0c\u800c\u7d30\u80de\u6838\u7684\u76f4\u5f91\u537b\u53ea\u6709\u7d04 5 \u5230 10 \u5fae\u7c73\u3002\u5f9e\u5c3a\u5ea6\u8b8a\u5316\u4e0a\u4e0d\u96e3\u770b\u51fa\uff0c\u7d30\u80de\u6838\u5167\u7684DNA\u6703\u662f\u4ee5\u6298\u758a\u7684\u65b9\u5f0f\u4fdd\u5b58\u7684\u3002\u5728\u7d30\u80de\u5206\u88c2\u9593\u671f\u6642\uff0c\u67d3\u8272\u8cea\u5be6\u969b\u4e0a\u662f\u6563\u958b\u4e00\u5718\u7684\u65b9\u5f0f\u5b58\u5728\u65bc\u7d30\u80de\u6838\u5167\u3002\u5e38\u898b\u7684\u68d2\u72c0\u67d3\u8272\u9ad4\u662f\u300c\u7d30\u80de\u5206\u88c2\u671f\u300d\uff0c\u5c24\u5176\u662f\u6709\u7d72\u5206\u88c2\u4e2d\u671f\uff08metaphase\uff09\u6642\u624d\u6703\u88ab\u6253\u5305\u7684\u578b\u614b\u3002\u67d3\u8272\u8cea\u5e73\u6642\u662f\u6563\u6210\u4e00\u5718\uff0c\u537b\u4e26\u975e\u96a8\u6a5f\u7684\u4e00\u5718\uff0c\u800c\u662f\u4fdd\u6709\u7279\u5b9a\u76f8\u5c0d\u4f4d\u7f6e\u95dc\u4fc2\u7684\u65b9\u5f0f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img decoding=\"async\" width=\"1024\" height=\"465\" src=\"https:\/\/ml4fi34j3t2e.i.optimole.com\/w:1024\/h:465\/q:mauto\/f:avif\/https:\/\/www.next-bioinfo.tw\/wp-content\/uploads\/2026\/10\/01.png\" alt=\"\" class=\"wp-image-544\" style=\"aspect-ratio:2.2021505376344086;width:482px;height:auto\"\/><\/figure>\n\n\n\n<p>\u7279\u5225\u662f\u67d3\u8272\u8cea\u7684\u8cc7\u8a0a\u88ab\u7d30\u80de\u8b80\u53d6\u8f49\u9304\u6642\uff0c\u6703\u5f62\u6210\u7279\u6b8a\u7684\u6298\u758a\u5f62\u5f0f\uff0c\u5176\u4e2d\u4e00\u7a2e\u6700\u5e38\u898b\u7684\u985e\u578b\u7a31\u70ba\u589e\u5f37\u5b50-\u555f\u52d5\u5b50\u74b0(E-P Loop)\u3002\u589e\u5f37\u5b50\u662f\u7279\u5b9a\u5340\u57df\u7684\u67d3\u8272\u8cea\u5c0d\u53e6\u5916\u4e00\u7aef\u8f49\u9304\u8d77\u59cb\u5340\u5177\u6709\u589e\u5f37\u6307\u4ee4\u4f5c\u7528\u7684\u7de8\u78bc\uff0c\u7531\u65bc\u5169\u6bb5\u5340\u57df\u4e0d\u662f\u76f4\u63a5\u5728\u76f8\u9130\u5340\u57df\uff0c\u56e0\u6b64\u5be6\u969b\u4e0a\u662f\u900f\u904e\u5f4e\u6298\u7dda\u6bb5\u7684\u65b9\u5f0f\u8b93\u5169\u7aef\u7269\u7406\u76f8\u5c0d\u4f4d\u7f6e\u9130\u8fd1\u7684\uff0c\u56e0\u6b64\u6298\u5f4e\u7684\u9019\u500b\u7d50\u69cb\u7a31\u589e\u5f37\u5b50-\u555f\u52d5\u5b50\u74b0(E-P Loop)\u3002\u800cE-P Loop\u4e0d\u4e00\u5b9a\u662f\u8f49\u9304\u6642\u624d\u5b58\u5728\uff0c\u6709\u4e9b\u662f\u7a69\u5b9a\u5b58\u5728\uff0c\u56e0\u6b64\u67d3\u8272\u8cea\u5e8f\u5217\u7684\u7269\u7406\u7a7a\u9593\u76f8\u5c0d\u4f4d\u7f6e\u5176\u5be6\u626e\u6f14\u4e86\u8abf\u63a7\u6a5f\u5236\u7684\u7a0b\u5e8f\u3002<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img decoding=\"async\" width=\"900\" height=\"583\" src=\"https:\/\/ml4fi34j3t2e.i.optimole.com\/w:auto\/h:auto\/q:mauto\/f:avif\/https:\/\/www.next-bioinfo.tw\/wp-content\/uploads\/2026\/10\/02.png\" alt=\"\" class=\"wp-image-542\" style=\"aspect-ratio:1.5437392795883362;width:406px;height:auto\"\/><\/figure>\n\n\n\n<p>\u5927\u5bb6\u5e38\u8aaa\u7684\u57fa\u56e0\u662f\u6307\u4eba\u985e\u7684DNA\u96d9\u80a1\u87ba\u4e0a\u7684\u4e00\u6bb5\u7de8\u78bc(ATCG\u7684\u5e8f\u5217)\uff0c\u5b83\u5c0d\u61c9\u5230\u8981\u88ab\u7d30\u80de\u88fd\u9020\u7684\u86cb\u767d\u8cea\u7684\u8cc7\u8a0a\u3002\u7136\u800c\uff0c\u6709\u57fa\u56e0\u7684\u7de8\u78bc\uff0c\u4e0d\u4ee3\u8868\u8a72\u57fa\u56e0\u5c0d\u61c9\u5230\u7684\u86cb\u767d\u8cea\u4e00\u5b9a\u6703\u88ab\u751f\u6210\uff0c\u7d30\u80de\u5be6\u969b\u4e0a\u662f\u52d5\u614b\u5728\u201d\u6c7a\u5b9a\u201d\u8981\u4e0d\u8981\u751f\u7522\u54ea\u4e9b\u86cb\u767d\u8cea\uff0c\u800c\u9019\u7a2e\u904e\u7a0b\u7a31\u70ba\u8abf\u63a7\u3002\u6700\u7c21\u55ae\u7684\u4f8b\u5b50\u662f\u540c\u4e00\u500b\u4eba\u7684\u624b\u6307\u7d30\u80de\u8ddf\u80c3\u7d30\u80de\u7684DNA\u5b8c\u5168\u4e00\u6a23\uff0c\u4f46\u624b\u6307\u4e0d\u6703\u5206\u6ccc\u80c3\u9178\uff0c\u9019\u662f\u56e0\u70ba\u80c3\u7d30\u80de\u7684ATP4A CA2 \u7de8\u78bc\u7684\u76f8\u95dc\u57fa\u56e0\u6d3b\u5316\u4e4b\u5f8c\uff0cCA2 \u57fa\u56e0\u6240\u7de8\u78bc\u7684\u78b3\u9178\u9150\u9176(\u9176\u5c31\u662f\u86cb\u767d\u8cea\uff0c\u53c8\u7a31\u9175\u7d20)\u6703\u615b\u5316\u8b93CO2+H2O\u7522\u751f\u53cd\u61c9\u751f\u6210\u751f\u6210\u6c2b\u96e2\u5b50\uff0c\u518d\u7531 ATP4A\u3001ATP4B \u7de8\u78bc\u7684\u8cea\u5b50\u5e6b\u6d66\u5c07\u6c2b\u96e2\u5b50\u904b\u9001\u81f3\u80c3\u8154\uff0c\u7136\u5f8c\u8207\u8490\u96c6\u5230\u7684\u6c2f\u96e2\u5b50\u751f\u6210\u9e7d\u9178(HCL)\u3002\u624b\u6307\u6c92\u6709\u751f\u6210\u80c3\u9178\u7684\u6574\u5957\u6a5f\u5236\uff0c\u81ea\u7136\u4e0d\u6703\u7522\u751f\u5316\u5b78\u53cd\u61c9\u751f\u6210\u7269\u8cea\u3002\u9019\u5c31\u662f\u6240\u8b02\u7684\u8abf\u63a7\u6a5f\u5236\u3002\u800c\u524d\u8ff0\u63d0\u5230\u7684\u67d3\u8272\u8cea\u5f4e\u6298\uff0c\u4e00\u5718\u7684\u5f62\u5f0f\uff0c\u81ea\u7136\u548c\u8abf\u63a7\u6a5f\u5236\u6709\u95dc\u3002\u9664\u4e86\u524d\u8ff0\u57fa\u56e0\u8abf\u63a7\u9084\u6d89\u53ca DNA \u7532\u57fa\u5316\u3001\u7d44\u86cb\u767d\u4e59\u91af\u5316\u8207\u7532\u57fa\u5316\u7b49\u591a\u7a2e\u5206\u5b50\u4fee\u98fe\u6a5f\u5236\uff0c\u56e0\u6b64\u6574\u500b\u8abf\u63a7\u7cfb\u7d71\u5341\u5206\u8907\u96dc\u3002<\/p>\n\n\n\n<p>\u4e5f\u56e0\u6b64\uff0c\u67d3\u8272\u8cea\u7684\u4e09\u7dad\u76f8\u5c0d\u4f4d\u7f6e\u7684\u95dc\u4fc2\u662f\u7814\u7a76\u5e95\u5c64\u5206\u5b50\u751f\u7269\u6a5f\u5236\u7684\u524d\u6cbf\u7684\u7814\u7a76\u9818\u57df\u3002\u76ee\u524d\u4eba\u985e\u50c5\u78ba\u5207\u77e5\u9053DNA\u96d9\u80a1\u87ba\u4e0a\u7684\u7de8\u78bc\u70ba\u4f55\uff0c\u537b\u4ecd\u4e0d\u6e05\u695a\u8a73\u7d30\u5177\u9ad4\u8b80\u53d6\u9019\u4e9b\u7de8\u78bc\u7522\u751f\u5316\u5b78\u53cd\u61c9\u8f38\u51fa\u7684\u8907\u96dc\u52d5\u614b\u6a5f\u5236\u3002\u5728\u9019\u9818\u57df\u5df2\u77e5\u7684\u4e8b\u5be6\u662f\uff0c\u8981\u7522\u751f\u524d\u8ff0\u63d0\u53ca\u7684\u67d3\u8272\u8cea\u74b0\u6709\u5177\u9ad4\u7684\u86cb\u767d\u8cea\u8207\u6d41\u7a0b\uff0c\u4e5f\u5c31\u662fCTCF\u3001cohesin \u8207 loop extrusion \u5982\u4f55\u52d5\u614b\u6298\u758a\u51fa\u67d3\u8272\u8cea\u74b0\u3002\u4f46\u6211\u5011\u5c0d\u65bc\u67d3\u8272\u8cea\u4e4b\u9593\uff0c\u4ee5\u53ca\u7d30\u80de\u5206\u5b50\u4e4b\u9593\uff0c\u5982\u4f55\u52d5\u614b\u5206\u914d\u67d3\u8272\u8cea\u7684\u76f8\u5c0d\u4f4d\u7f6e\u4ecd\u6240\u77e5\u751a\u5c11\u3002\u4e00\u500b\u5047\u8a2d\u662f\uff0c\u9019\u4e9b\u67d3\u8272\u8cea\u4e4b\u9593\u5728\u7269\u7406\u7a7a\u9593\u4e2d\u7684\u76f8\u5c0d\u4f4d\u7f6e\u5f88\u53ef\u80fd\u672c\u8eab\u5c31\u662f\u6f14\u5316\u96b1\u5f0f\u4fdd\u5b58\u4e00\u5b9a\u8abf\u63a7\u8cc7\u8a0a\u7684\u201d\u5730\u65b9\u201d\u3002\u56e0\u6b64\uff0c\u6709\u5c08\u9580\u9818\u57df\u7814\u7a76\u9019\u584a\uff0c\u7a31\u4e4b\u70ba\u67d3\u8272\u9ad4\u4e09\u7dad\u7d50\u69cb\uff0c\u6216\u662f\u67d3\u8272\u9ad4\u4e09\u7dad\u7d44\u7e54(3D Chromatin 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